Hamilton Health Sciences: We Are Explorers

Redefining “Research”

By Ted Scott, Acting Vice President Research & Chief Innovation Officer, @Chief_Innovator 

The dictionary definition of “researcher” is painfully self-explanatory: “someone who conducts research.” Based on my experience at Hamilton Health Sciences over the last few years, this description does no justice.

The word “research” itself has attracted a certain connotation that invokes images of anonymous individuals in lab coats analyzing samples in whitewashed, sterile rooms in the pursuit of some far-off, seemingly impossible discovery. Sure, some discovery happens that way. But, so often, it’s so much more than that.

At HHS, our researchers are so much more than people in lab coats. They are innovative, strategic, highly creative minds who translate complex data into new knowledge. Many of our researchers are also healthcare providers. Every day, they work alongside the patients who are the inspiration for their research pursuits. Their “labs” are patients’ rooms, clinics, and operating theatres. Every day, they’re on the front lines of our healthcare system, asking questions and solving problems. Their roles span the entire spectrum of healthcare professions: they’re surgeons, pediatricians, physiotherapists, nurses, students. They’re also our neighbours, friends, family members and, sometimes, they’re patients, too.

In my short time at HHS, I’ve learned that our researchers are also some of our community’s top innovators and collaborators. They’re forming networks across our city and region that are aimed at improving the way we provide healthcare, applying technology and expertise to make our healthcare system better. And, most importantly, their work has immense, tangible impact. Beyond the lab and the computer database, our nearly 2,000 researchers and research staff are discovering and implementing new knowledge that’s changing the way we care for people, in real-time.

For example, they’re testing in-home technology that our nurses and doctors can use to monitor patients once they go home after heart surgery. They’re working with tech innovators to find better ways of predicting outcomes for cancer therapies, so patients can make better decisions around their treatment options. They’re trialling the latest therapies to help make life easier for kids with chronic diseases, like IBD.

This is just a sampling of the research happening at our hospitals, right now. It wouldn’t be possible without our researchers and research staff who are unwavering in their pursuit of making life better for people in our community, across our country, and around the world.

I admire their persistence, their patience, and their will to keep exploring, even when the answers aren’t clear. And especially when competing commitments – of being doctors, nurses, allied health professionals, students – are as demanding as they are in our very busy health system.

It’s this insatiable drive to know the unknown that I believe better defines a researcher, no matter how big or small the issue at hand.

At HHS, we’re redefining what “research” means to our community, and to the world.

We’re not just researchers. We are explorers. It’s in our DNA.

Read about Explorers at Hamilton Health Sciences:

BLOG: Creating a new treatment option

 

BLOG: The stubborn pursuit of “Why”

      

For more, visit WeAreExplorers.ca 

#WeAreExplorers #onHWS

 

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Hamilton Health Sciences is one of Ontario’s 23 research hospitals that contribute to a healthier, wealthier, smarter province. Look for other RESEARCH SPOTLIGHT posts on our Healthier, Wealthier, Smarter blog or join the conversation about why health research matters for Ontario on Twitter, using the hashtag #onHWS.

 

 

Canadian First: SickKids and Sinai Health System repair spina bifida in-utero

In a Canadian first, a team from Mount Sinai Hospital and The Hospital for Sick Children (SickKids) has repaired a form of spina bifida in a fetus at 25 weeks gestation. The baby’s mother, Romeila Son, recovered very well from surgery, and a bouncing baby girl, Eiko, weighing 2.45 kg, was born on August 19 at 36 weeks gestation at Mount Sinai Hospital. Since her birth, Eiko has needed no further intervention for this usually debilitating condition. This is the first case in Canada where the mother has not had to travel to the United States for this specialized surgery.

Dr. Greg Ryan heads Canada’s largest and most experienced fetal therapy program at Mount Sinai Hospital and Dr. James Drake heads Canada’s largest and most established neurosurgical centre for the postnatal repair of spina bifida at SickKids. Working in collaboration with colleagues from Vanderbilt University in Nashville who pioneered the procedure, a team of 24 clinicians led by Drs. Ryan and Drake successfully carried out the 2.5 hour in-utero procedure at Mount Sinai on June 4, 2017.


From left: Dr. Michael Apkon, President & Chief Executive Officer, SickKids; Dr. Paige Church, Head of spina bifida clinic at Holland Bloorview Kids Rehabilitation Hospital; Dr. James Drake, Head of Neurosurgery, SickKids;  Premier of Ontario, Kathleen Wynne; Dr. Greg Ryan, Head of Fetal Medicine program, Mount Sinai Hospital; Romeo Crisostomo, Eiko’s dad; Romeila Son, Eiko’s mom; baby Eiko Crisostomo; Dr. Mathew Sermer, Obstetrician and Gynaecologist-in-Chief, Sinai Health System; Dr. Gary Newton, President and Chief Executive Officer, Sinai Health System.

What is spina bifida?

Myelomeningocele is a form of spina bifida, affecting approximately 120-150 babies in Canada each year. It is caused when the spinal column fails to close early in fetal development, causing permanent damage to the baby’s spinal cord and nervous system.

Babies with spina bifida can have varying degrees of paralysis of their lower limbs and many will need mobility supports such as leg braces, crutches or wheelchairs. Over 80 per cent of children with spina bifida will require a shunt to be inserted to relieve pressure on their brain, which must remain in place for their entire life, and some affected children will have a negative neurocognitive outcome. Between 15-30 per cent of children with spina bifida do not survive into adulthood and less than 50 per cent live independently as adults. A third of adults with spina bifida require substantial lifelong daily support. The emotional, social and financial impact for these affected individuals, their families and society as a whole, is enormous.

Better treatment option for babies

The Management of Myelomeningocele Study (MOMS), a groundbreaking trial published by Vanderbilt University, Children’s Hospital of Philadelphia and the University of California, San Francisco, in the New England Journal of Medicine in 2011, showed that, in babies who underwent the in-utero procedure:

  • Brain malformations were reversed by one-third
  • The need for walking aids or a wheelchair was halved
  • Their need for brain shunts was reduced by half

Consequently, the Society of Obstetrics and Gynaecologists of Canada (SOGC) now mandates that any pregnant woman whose fetus has spina bifida must be counselled about this treatment option.

“Although fetal surgery will not be appropriate for all fetuses with spina bifida, it is extremely encouraging that, for some, it may preserve neuromotor function, reverse brain herniation and reduce their need for a brain shunt,” said Dr. Greg Ryan, head of the fetal medicine program at Mount Sinai Hospital, part of the Frances Bloomberg Centre for Women’s and Infants’ Health. “However, it also entails some maternal and fetal risks, particularly that of premature labour, which must be carefully balanced.”

“We regularly see children who have been affected by spina bifida at SickKids,” said Dr. James Drake, head of the division of neurosurgery and senior associate scientist at SickKids. “It is my hope that our capacity to perform this in-utero surgery here in Toronto will mean that we can optimize their clinical outcomes, and reduce the degree of medical challenges these children will face.”

Collaboration counts

“I am extremely proud of the collaboration between Mount Sinai Hospital and SickKids – which has resulted in a terrific outcome for this baby girl,” said Dr. Ryan.”Having this kind of clinical capacity here in Ontario will really change the range of options available to parents who have been given a diagnosis of spina bifida during pregnancy.”

“I would like to congratulate everyone at Mount Sinai Hospital and SickKids who teamed up to perform Canada’s first in-utero spina bifida surgery,” said the Honourable Kathleen Wynne, Premier of Ontario. “The incredible story of baby Eiko’s journey into this world shines a bright light on our world-class health care professionals. They’re talented, innovative, and making life better for people in this province — starting even before they’re born. Congratulations to little Eiko and her family. I wish them a healthy, happy future.”

Mount Sinai Hospital and SickKids recently collaborated on another in-utero surgical first, repairing a congenital heart defect called transposition of the great arteries, in May, 2017. The team from SickKids and Mount Sinai Hospital is Canada’s only provider of fetal surgery.

Read the original press release of this Canadian First here.

*Feature photo: From left: Premier of Ontario, Kathleen Wynne; Dr. James Drake, Head of Neurosurgery, SickKids; Romeo Crisostomo, Eiko’s dad; baby Eiko Crisostomo; Romeila Son, Eiko’s mom; ; Dr. Greg Ryan, Head of Fetal Medicine program, Mount Sinai Hospital.

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SickKids and Sinai Health System are two of Ontario’s 23 research hospitals that contribute to a healthier, wealthier, smarter province. Look for other RESEARCH SPOTLIGHT posts on our Healthier, Wealthier, Smarter blog or join the conversation about why health research matters for Ontario on Twitter, using the hashtag #onHWS.

HIV care that’s made for women

Women are one of the fastest growing populations at risk for HIV infection and they have worse clinical outcomes than men do.

Dr. Mona Loutfy, a senior scientist at Women’s College Research Institute, is developing HIV care designed especially for women’s needs to close the health gaps they experience.

Dr. Loutfy leads the Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CHIWOS), a national study funded by the Canadian Institutes of Health Research. The study’s goal is to help women with HIV be as healthy as they can be in every way.

Study findings have shown that women in Canada receive good treatment for their HIV but their overall women’s health needs — including pregnancy planning, Pap testing, mammograms and mental health care — are often overlooked. To find and address these gaps, Dr. Loutfy engages women with HIV and their communities to ensure their concerns drive her research questions.

“When we set out to look at what we thought as researchers, were the most important topics, we thought it was going to be all about delivery of HIV care. What came out was actually a bit different.”

The study found that 64 per cent of the women had experienced violence in childhood and 80 per cent had experienced violence in adulthood. Half of the women had depressive symptoms. Isolation and poverty were also significant issues in the community.

“I feel that the care needs to be a little bit different,” Dr. Loutfy says.

She is working to create a new model of care that is women-centred, meaning focused on optimizing the overall health of women with HIV in Canada, particularly those at a higher risk, such as Indigenous women and trans women.

For women like Evana Ortigoza, a Community Advocate with Dr. Loutfy’s Trans Women HIV Research Initiative, the effort is very important. Evana is a trans woman who has lived with HIV for 17 years.

“The research they’re doing here is for trans and women, women with kids and women in all their diversity; it’s amazing. We are not alone,” she says. “Everywhere I go, Women’s College is there to make sure that women are protected.”

Watch the video above to learn more about Evana and Dr. Loutfy’s research, and visit report2017.womensresearch.ca to learn more about research at Women’s College Research Institute at Women’s College Hospital.

 

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Women’s College Hospital is one of Ontario’s 23 research hospitals that contribute to a healthier, wealthier, smarter province. Look for other RESEARCH SPOTLIGHT posts on our Healthier, Wealthier, Smarter blog or join the conversation about why health research matters for Ontario on Twitter, using the hashtag #onHWS.

Celebrating Science and Innovation across CAHO Hospitals

On October 25th, the Council of Academic Hospitals of Ontario (CAHO) held its 3rd Healthier, Wealthier, Smarter Health Research Showcase at Queen’s Park to demonstrate and celebrate the breadth and depth of health research underway across Ontario’s 23 research hospitals.

“Today’s slogan is that health research makes Ontario healthier, wealthier and smarter. I believe that’s true, but I would add that health research also gives us the opportunity to be better,” said Bill Bishop, who spoke at our showcase about his experience participating in a metabolic syndrome research study with Dr. Amer Johri at Kingston Health Science Centre. Read more about that research in a previous blog post.


Bill Bishop, metabolic syndrome research volunteer from Kingston Health Sciences Centre, shares his experience and thoughts on the value of research for Ontario.  

“Investing and participating in health research is not an opportunity to give back, but an opportunity to give forward, to future generations,” Bill continued. “It often happens that, while doing the research on one specific thing, new and different things are discovered. By investing and participating in research, we are better citizens.”

An inspiring morning, our showcase welcomed nearly 30 Ministers, MPPs, Government Officials and Queen’s Park staff into a room full of science and innovation to meet the amazing researchers who make it happen.

“It really takes a special kind of person to do research,” said CAHO Chair, Kevin Smith. “Today we celebrate not only the product, but the people. In partnership with our University and College partners, research-intensive hospitals are here to help scientists drive research that really matters to the people of Ontario, Canada and the world.”


Dr. Martin Osmond, Vice President of Research at Children’s Hospital of Eastern Ontario (CHEO), tests out Botley’s Bootle Blast, a mixed reality rehabilitation therapy game developed by researchers at Holland Bloorview Kids Rehabilitation Hospital.  


Our showcase was a meeting of the minds – literally! Researchers at Sunnybrook Health Sciences Centre are using focused ultrasound technology to open the blood-brain barrier in people with Alzheimer’s disease to get therapies safely and directly into the brain.


Can we generate a kidney for human transplant by replacing cells in a pig’s kidney with a patient’s own cells? Dr. Ian Rogers and Tonya Bongolan from Sinai Health System share their research with Minister Reza Moridi. 

Part of the celebration also included remarks from Minister of Research, Science and Innovation, Reza Moridi, who has been a strong champion of health research in Ontario. Minister Moridi described how some cancer diagnoses that would likely have been fatal 25 years ago are treatable today and, in some cases, are even curable thanks to discovery and the dedication of researchers. This is the real impact that health research has on the daily lives of people in this province.


Minister Reza Moridi speaks to the audience at CAHO’s 3rd Healthier, Wealthier, Smarter Health Research Showcase 

The showcase was buzzing with over 100 representatives from CAHO member hospitals in the room, and over 230 voices engaging on our #onHWS hashtag, which trended at number one in Canada throughout the morning.

DOWNLOAD the summary of research on display.

SCROLL through our live tweet summary.

LEARN more about CAHO hospitals.

Read more blog posts on our Healthier, Wealthier, Smarter site and share your insights on Twitter with the hashtag, #onHWS. To learn more about how health research makes Ontario healthier, wealthier, and smarter, check out our website and our other blog posts and videos.

*Feature Photo: Drs. Gianluigi Bisleri and Ben Glover form Kingston Health Sciences Centre showcase their innovative 3D cardiac ablation procedure – a Canadian first.

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Health and Community Leaders Talk: Ted Scott

For this Health and Community Leaders Talk blog post, we’re focusing on the value of Ontario’s Innovation Brokers. Supported by a task force of executive leaders from across Ontario’s research hospitals, the Council of Academic Hospitals of Ontario (CAHO) began its work as an Innovation Broker in April 2017, in partnership with the Ontario Chief Health Innovation Strategist (OCHIS).

CAHO’s Innovation Broker task force is co-chaired by Ted Scott, Acting Vice President Research & Chief Innovation Officer at Hamilton Health Sciences. We sat down with Ted to get his take on why the Innovation Broker work is important, and how it makes Ontario healthier, wealthier and smarter.

What inspired you to be involved with CAHO’s work as an Innovation Broker?

In my role as Chief Innovation Officer at Hamilton Health Sciences (HHS), I am helping to create a culture of collaboration and working to connect our clinical experts and scientists to high potential digital health companies to develop innovative clinical care models. My work at HHS is really well aligned to the Innovation Broker mandate and I’m excited to help make it easier for companies to get their innovations into Ontario’s research hospitals. At the end of the day, this will improve care and make our health system more efficient for our patients.

What’s in it for innovators?

The CAHO Innovation Broker work provides new opportunities for companies and research hospitals to work together to develop solutions and drive innovation adoption across the province. It also provides companies with stronger and more meaningful feedback on their innovations, allowing them to iterate and develop more relevant and marketable products.

At a larger scale, CAHO’s Innovation Broker work is helping to grow a culture of innovation within Ontario’s research hospitals and developing better processes to pull innovations into our organizations. We know that one of the toughest barriers companies face on the long path to market is connecting with those early adopters who are willing to test-drive innovations that will lead to better care. Through our Innovation Broker role, companies only have to knock on one door to gain access to Ontario’s 23 research hospitals, making those first connections a lot faster and easier.

Our hope is that this not only makes it easier for innovators to partner with us today, but that we’re building a better system and better partnerships to improve innovation adoption long into the future.

How can Ontario’s Innovation Broker work help fuel a healthier, wealthier, smarter province?

The Innovation Broker work is really about re-thinking how we deliver healthcare. By providing a streamlined and transparent process for connecting healthcare providers and innovative companies, we will be able to do a better job of providing care and drive economic growth at the same time. Collectively, Ontario’s Innovation Brokers are working to deliver a healthcare system powered by our world-leading research community in collaboration with our most promising industry partners. A more innovative health system is definitely a future we can all work towards.

  • Visit the CAHO website to learn more about our Innovation Broker work and how you can be involved.
  • Visit the OCHIS website to learn more about Ontario’s Innovation Brokers.

 

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Read more Health and Community Leaders Talk blog posts on our Healthier, Wealthier, Smarter site and share your insights on Twitter with the hashtag, #onHWS. To learn more about how health research makes Ontario healthier, wealthier, and smarter, check out our website and our other blog posts and videos.

Research Spotlight: North York General Hospital

Research Chairs Poised to Ask the Right Questions 

As a leading community academic hospital, North York General Hospital (NYGH) is uniquely positioned to transform and enhance patient care through continuous evolution. In 2011, the hospital released Strategy 2015-2018, which envisioned the achievement of excellence in integrated patient-centred care through learning, innovation and partnership. To achieve this stratagem, research and innovation plays a central role assuring the necessary evolution contributing to quality, efficiency and excellence in patient-centred care. The creation of the first-ever research chairs was a key part of building on the academic foundation.

“We know the majority of hospital care in Canada is provided in community hospitals, so the scholarly work we do will make a difference well beyond our catchment areas,” says Dr. Donna McRitchie, Vice President, Medical & Academic Affairs. “Our strategy for research and innovation is built around our research chairs, who will explore new ways to improve processes for delivering care.”

To date, North York General has recruited four research chairs, beginning with the recruitment of the Gordon F. Cheesbrough Research Chair in Family and Community Medicine, named after one of North York General’s greatest leaders and champions, and the first of its kind in Canada. The Chair’s purpose is to drive interdisciplinary, interprofessional and crossinstitutional research investigations, with the goal of enhancing the quality and outcomes of care provided at the individual and system level. Until recently the position was held by Dr. Frank Sullivan. NYGH is currently recruiting for the role.

Dr. Monika Kastner NYGK

Monika Kastner joined NYGH in February 2016 as the Research Chair in Knowledge Translation and Implementation. Knowledge translation is regarded as a bridge between the creation and implementation of knowledge and as such, it is highly relevant to NYGH strategic objectives.

“There is so much important work in health care research that is underutilized simply because we do not have adequate processes and channels for implementation and dissemination,” Monika says. “I’m interested in bridging that gap to help enhance the uptake of services and products for patients and families.”

North York General Hospital (NYGH) recently welcomed Patricia Trbovich

Patricia Trbovich joined the hospital in August 2016 as the Badeau Family Research Chair in Patient Safety and Quality Improvement. In her role, she focuses on reducing preventable medical errors and creating innovative solutions in a community academic hospital setting to enhance patient safety and quality of care.

“We have to proactively identify risks and mitigate them before they cause harm, as opposed to solely reacting once adverse events have already occurred,” Patricia says. “We have to embrace complexity and figure out where it’s needed and where we can reduce it.”

As the newest member recruited in August 2017, Katie Dainty, PhD, is the hospital’s Research Chair in Patient-Centred Outcomes. Katie is interested in finding new ways to enhance this experience by applying an often-ignored lens: the patient’s perspective.

NYGH Katie Dainty

“It’s important to remember that even if the care was clinically perfect, a patient’s life may be changed dramatically and they have to deal with after effects, both physically and psychologically,” Katie says. “The question is: what can we do leading up to, during and after hospital care to ensure there is the best possible long-term outcome for the patient and their family?”

The appointment of hospital research chairs is part of NYGH’s overall strategy to transform care through applied research and innovation. The hospital is immensely grateful to the North York General Foundation for their support in establishing these Research Chairs.

North York General Hospital is one of Ontario’s 23 research hospitals that contribute to a healthier, wealthier, smarter province. Read more Research Spotlight posts and other patient and researcher stories on our Healthier, Wealthier, Smarter blog or join the conversation about why health research matters for Ontario on Twitter, using the hashtag #onHWS.

 

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Moving Forward on Meaningful Patient Engagement in Research

When patients and families have a place at the table, Ontario research hospitals can do a better job making our province healthier, wealthier, and smarter. As we have heard from so many patients, families, and patient advocates in our Patients + Research blog series, the patient voice plays an invaluable role in supporting, improving and empowering health research.

As part of our strategic plan, CAHO and its members are committed to driving best practices in patient and public involvement, engagement and participation in health research. To move this forward, CAHO established a Community of Practice comprising patients, caregivers and hospital staff from across our member hospitals. Collectively, this group will drive meaningful patient engagement forward by championing and implementing best practices in their own communities, and across the province.

During our recent visit to Kingston Health Sciences Centre for the grand opening of the W.J. Henderson Centre for Patient-Oriented Research, we saw many examples of meaningful patient engagement. Dr. Amer Johri, a clinician-scientist at the Kingston Health Sciences Centre and a Queen’s University professor, is one such example. Through his work on metabolic syndrome – a complex condition that includes obesity, high blood pressure, high cholesterol and diabetes – with the CINQ lab (Cardiovascular Imaging Network at Queen’s), Dr. Johri is leading the way on involving patients in the research process.

Recently, Dr. Johri and his team invited Kingston community members living with metabolic syndrome to share their experiences and, more significantly, to suggest where future research efforts should be directed.


A focus group of Kingston community members living with metabolic syndrome share their suggestions for future research.

“Hearing the patient perspective is critical to advancing research and improving care. We can enable patients who live with this condition every day to guide future research, programs and care,” said Dr. Johri. “This focus group method has had a meaningful impact on our work. That’s not only exciting for how we conduct studies within our own lab, but hopefully it can inspire other research partners to involve patients in their process and improve the quality of their studies by making modifications based on patient feedback.”

Dr. Johri’s approach is one example of the work being done across CAHO hospitals to move forward on meaningful patient engagement in research. His focus group was a collaboration between the CINQ lab and Metabolic Syndrome Canada. The CINQ Lab is funded by the Canada Foundation for Innovation and the Heart and Stroke Foundation of Canada.

Dr. Amer Johri metabolic research
Dr. Amer Johri shares his latest research on metabolic syndrome with local community members. 

Dr. Johri is one of many Kingston clinicians who will now be able to conduct research and meet with patients at the new W.J. Henderson Centre for Patient-Oriented Research, which opened on September 11, 2017. He hopes to host a yearly Metabolic Syndrome Day for Kingston community members at the new research facility.

“This new space gives us a place to host events, meet with patients and families, and talk about their experiences,” said Dr. Johri. “Patients now have a ‘home base’ for participating in research. A place that is familiar, welcoming and belongs just as much to them as it does to the researchers and hospital staff.”


Brand new space dedicated to patient-oriented research in Kingston /// Photo and feature photo: Matthew Manor, Kingston Health Sciences Centre

The new facility adds 10,000 square feet of dedicated research space to the Kingston General Health Research Institute, which is home to 700 active research projects, 273 active clinical trials, 250 researchers, 153 students and trainees, and 313 research staff.

By creating a space for partnership and collaboration among scientists, treatment teams, patients and families, this new facility will benefit the Kingston community today, while serving as a guidepost for Ontario health research tomorrow.

 

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Add Your Voice

Want to share your insights on why health research matters for Ontario? Email or call Elise Bradt at ebradt@caho-hospitals.com, 416-205-1469, or direct message or tweet at us on Twitter at @CAHOhospitals.

Read more Patients + Research posts and share your own insights on Twitter with the hashtag #onHWS. To learn more about how health research makes Ontario healthier, wealthier and smarter, visit our impact page, and check out our other blog posts and videos.

Patients + Research: Annette McKinnon

At 32 I was a mom to two boys and working part time. When I started to have problems with my hands, feet and overall exhaustion, of course I went to see my doctor. He kept telling me I was just a normal busy mom. This caused a delay of more than a year before I got a diagnosis of Rheumatoid Arthritis. By then my joints had a lot of damage. It was hard for me and for my family to accept this new ‘normal’ in our lives.

Patient Advocate Annette McKinnonOften chronic disease makes people feel depressed and I was no exception, but between my determined physio and a clinical trial of a new drug that my doctor suggested, I was able to reach a turning point.  The positive feedback I got from one of the trial doctors made me realize that even with health problems I could change my life through my own actions.

That encouragement led me to try to find and use research papers from PubMed and to share what I learned about RA in private health groups and on Twitter.  A friend called it evidence-based tweeting.

Through these efforts I attended an IDEO design thinking workshop. Every patient was partnered with a group of Health Care Professionals and we spent a day of developing a prototype solution for a patient issue – mine was communication between doctor and patient. We created very effective solutions and I thought my team was brilliant. It wasn’t till the next day that I credited myself with having been a team member too.

Because of this conviction of the value of patient knowledge and the patient voice I have persisted in trying to be a patient who is involved in many aspects of the health system.

The first time I was involved in research, as a patient member on a research team, I thought I was helping out, and ended up as a co-author.

Since then I have been on research teams in Ontario applying for grants and also in doing the work after funding. It takes a lot of effort on both sides. The patient voice in research is especially necessary – I had found it shocking in the past to find doctors and researchers used to be the only ones who had input into which results were important to research, rather than finding out what was important to patients.

It has taken a long time for me to become a partner in research, rather than a subject who is being studied. This would have been impossible even ten years ago. I’m so pleased that at last the culture of health care is moving towards the inclusion of patients in meaningful ways.

Anyone who is an active patient will tell you that it is almost always done on a volunteer basis, but being involved has definitely made me healthier, and that’s worth more than money.

 

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Add Your Voice

Want to add your voice to the Patients + Research blog series? Email or call Elise Bradt at ebradt@caho-hospitals.com, 416-205-1469, or direct message or tweet at us on Twitter at @CAHOhospitals.

Read more Patients + Research posts and share your own insights on Twitter with the hashtag #onHWS. To learn more about how health research makes Ontario healthier, wealthier and smarter, visit our impact page, and check out our other blog posts and videos.

RESEARCH SPOTLIGHT: Hamilton Health Sciences

Hamilton researchers discover a simple blood test could save lives after surgery

Researchers at Hamilton Health Sciences’ Population Health Research Institute (PHRI) and McMaster University have determined that a simple blood test can predict and possibly prevent many of the deaths that occur after surgery.

“If death after surgery within the first 30 days was made its own category of death, it would be in the top 5 leading causes of death within North America,” explained Dr. P.J. Devereaux, principal investigator for the “VISION” study.

The VISION study enrolled nearly 22,000 patients aged 45 years or older from 23 hospitals in 13 countries and found that approximately 18 per cent of them sustained heart damage within 30 days of non-cardiac surgery and that, without enhanced monitoring, the vast majority – as many as 93 per cent – of these complications will go undetected, potentially until it’s too late to intervene.

Putting pressure on the heart

“The effects of surgery anywhere in the body create a perfect milieu for damage to heart tissue, including bleeding, blood clot formation, and long periods of inflammation,” says Dr. Devereaux, scientific leader of perioperative medicine at PHRI, director, division of cardiology at McMaster University. “In most cases, this damage occurs within the first 24 to 36 hours after surgery when patients usually receive narcotic painkillers that can mask symptoms of cardiac distress.”

“These discoveries have the potential to save lives.”

After surgery, study patients had a blood test for a protein called high-sensitivity troponin T, which is released into the bloodstream when injury to the heart occurs. Devereaux and his team discovered that patients with troponin T levels beyond a certain threshold had increased risk of death within 30 days of having surgery.

Overall, the study found that 1.4 per cent of patients died within 30 days following non-cardiac surgery.

“One per cent seems like a small number, until you consider that about 200 million surgeries are performed each year around the world,” says Devereaux. “Where we’re letting patients down is in post-operative management. We now know that we need to become more involved in care and monitoring after surgery to ensure that patients at risk have the best chance for a good recovery. These discoveries have the potential to save lives.”

The results of the VISION study were published in The Journal of the American Medical Association.

 

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Hamilton Health Sciences is one of Ontario’s 23 research hospitals that contribute to a healthier, wealthier, smarter province. Read more Research Spotlight posts on our Healthier, Wealthier, Smarter blog or join the conversation about why health research matters for Ontario on Twitter, using the hashtag #onHWS.

Health and Community Leaders Talk: David Hill

By David Hill, Scientific Director, Lawson Health Research Institute and Integrated Vice President of Research for London Health Sciences Centre and St. Joseph’s Health Care London

Dr David Hill Lawson Health Research Institute

What does health research mean to you?

Health research means delivering the best health care by pushing the boundaries of science. It’s about understanding the basis of wellness and the dysfunctions of the body and mind that result in disease. At Lawson, our research expands the full continuum of life and mirrors the clinical areas at London Health Sciences Centre and St. Joseph’s Health Care London. We make it our mission to test and deliver health care innovations for the benefit of patients in our community, in Ontario and beyond.

Health research also drives the future of health care—looking not just at where we are now but where we could be in ten or fifteen years. Ontario’s research hospitals bridge the gap between today’s discoveries and the next generation of health service and delivery. Where we could be won’t happen by chance. It will be the result of hospital-based research.

Read more: Behind the scenes at Lawson

How does health research contribute to a healthier, wealthier, smarter Ontario?

Healthier: Health research makes our patients healthier as the discovery of new treatments leads to improved health outcomes and a higher quality of life.  At Lawson, we take a “bedside to bench to bedside” approach. Our researchers focus their efforts on figuring out the clinical problem, and then take that back to the lab to develop new knowledge that can be translated directly to better patient care. At Lawson we built our strategic plan around precisely identified clinical problems and their resolution through inter-disciplinary research.

Wealthier: Health research is good for the economy as our researchers work to discover new ways to drive efficiency and reduce costs; find new methods of service delivery; improve procedures,; and create entirely new ones, like specialized molecular imaging techniques. We’re also commercializing our innovations through WORLDiscoveries®. Born out of a partnership between Lawson, Robarts Research Institute and Western University, WORLDiscoveries® is the business development arm of London’s extensive research network and the bridge between local invention and global industry.

Smarter: Health Research makes our communities smarter by attracting the best and brightest health care professionals. We’re seeing this at Lawson as we continue to grow our reputation as a leader in the life sciences sector, with over 1,500 principal investigators, research support staff, students and trainees. This growth feeds on itself, helping us to attract top talent to our city, like Dr. Chris McIntyre, a nephrology researcher who came to Lawson from the UK in 2014.

At Lawson, one thing we believe in strongly is that investment in health research is good for all of us – in London, across Ontario, and in Canada. In today’s tough funding landscape, we must ensure that health research remains a priority for health system leaders, and leaders in the broader community.

 

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Read more Health and Community Leaders Talk blog posts on our Healthier, Wealthier, Smarter site and share your insights on Twitter with the hashtag, #onHWS. To learn more about how health research makes Ontario healthier, wealthier, and smarter, check out our website and our other blog posts and videos.